[Source: Reuters]

Scientists in Israel have created a model of a human embryo from stem cells in the laboratory, without using sperm, eggs or a womb, offering a unique glimpse into the early stages of embryonic development.

The model resembles an embryo at day 14, when it acquires internal structures but before it lays down the foundations for body organs, according to the team at Israel’s Weizmann Institute of Science.

The scientists’ work was published in the journal Nature on Wednesday after a pre-print came out in June, during the International Society for Stem Cell Research (ISSCR)’s annual meeting in Boston.

The Israeli team emphasised that they were a long way from being able to create an embryo from scratch.

However, they said the work could open the door to new ways to test the effect of drugs on pregnancies, better understand miscarriages and genetic diseases, and perhaps even to grow transplant tissues and organs.

He said his team took stem cells derived from adult human skin cells, as well as others cultured in the lab, then reverted the cells to an early state with the potential to develop into different cell types.

They then manipulated them to form the basis of something structurally resembling an embryo. It is not an actual or synthetic embryo – a term criticised by the ISSCR and other scientists – rather a model showing how one works.

Their next goal, Hanna said, is to advance to day 21 and also reach a threshold of a 50% success rate.

Magdalena Żernicka-Goetz, a professor of development and stem cells at the University of Cambridge, said the study joins six other similar human embryo-like models published from teams around the world this year, including from her lab.

The study raises some ethical questions over the possibility of potential future manipulation in human embryo development, Hanna and others noted. He drew a comparison to nuclear physics, however, arguing that you should not stop all research in that field because somebody might choose to make a nuclear bomb.

It is important to engage and fully inform the public, he said, with “nothing done in the shadows”.